Genetics versus lifestyle disorders.
Key being- our smart Big Pharma scientists used to believe about 15-20 years ago, that after the age of small molecule- and antibody drug development, that the latest and greatest of those days - gene therapy- would solve all issues of mankind. Unfortunately for them, but GOOD for us, their thesis was totally wrong and genetic abnormalities tend to only cause about 10% of disorders and associated inconvenience. The bulk, 90% of our disorders we cause ourselves, or are caused by our environment, which includes our nutrition. To me that knowledge is wonderful news, since it gives almost anybody, a fighting chance to reverse a substantial part of their ailments and heal THEMSELVES to a large degree. We are also very lucky, that we do live at a time when spreading know-how through communications like the internet , is easy and affordable and that a lot of studies have been published to guide determined folks.
But to be honest- that 10% in relation to genetic information intrigues me too.
The Family heritage
One of the places to be able to gather information is 23andMe Inc - the Company of Sergey Brin´s former wife Anne Wojcicki. Unfortunately the FDA stopped the Company from providing genetic health information and one can nowadays only be served with ancestry stuff. That would be very boring information for me, since I do know where I come from.
Right below you see an image from 1946 or so of my wonderful parents, Fas and Cecilia Kuiters, who were always there when I needed them. Both died at a relatively young age and both were born in 1924. My father died in 1993, at age 69, from a total system collapse, caused by hepatitis type C, which he got through contaminated blood given to him during his by-pass surgery 3 years earlier at the Erasmus University Hospital in Rotterdam. This happened after leading a monogamous life without alcohol and tobacco. A horrific fate.
My mother minded the cats in our home in Germany, three years later in 1996, whilst I was on holiday with my family and suffered a severe heart attack. She never had cardiac issues, but suffered from rheumatoid arthritis and had pretty deformed hands as a result. I am 100% sure the lethal NSAID painkillers, which my practitioner in Maxdorf, (where I brought her once for check-up) said, were absolut killers and NOT allowed to be prescribed in Germany, have her on their conscience. On top of that, I am also convinced that inflammatory processes (like the one caused by rheumatoid arthritis) are much more dangerous to the vascular system as for instance cholesterol levels.
The above was basically an introduction to the "chances" of living a long life. My parents were unfortunately not very lucky, but as a further indication, I wanted to look at the male heritage line of my father, which is known until the 17th century i.e. six generations before him. i.e. the male parental line, and see how they fared in respect of age. The following facts emerge in respect of lifespan, which you can see in the image below. (Courtesy Hanno Kuiters- owner of the Geneanet.org Kuiters familytree)
Below the weapons of the Royal family of The Netherlands (The House of Orange) and the one of the first City in Holland, Dordrecht- you see the names listed of my forefathers, who all lived in Dordrecht. I am the first one who decided to escape crowded Holland and live elsewhere. Sofar- elsewhere has been the US, the UK and Germany. But anyway- those numbers I believe are kind of neutral and nothing saying, since life expectancy has been very different a few hunderd years back and these numbers are all over the place, kind of confirming that genetics play a very sub-ordinate role.
The Human Genome Project
- There are approximately 20,500 genes in human beings, the same range as in mice.
- The human genome has significantly more segmental duplications (nearly identical, repeated sections of DNA) than had been previously suspected.
- At the time when the draft sequence was published (in 2003) fewer than 7% of protein families appeared to be vertebrate (=species with backbone) specific.